Shorter Anogenital Distance in Women with Ovarian Endometriomas and Adenomyosis, but Not Uterine Leiomyomas

We investigated whether anogenital distance (AGD) is associated with adenomyosis, endometriosis and uterine leiomyomas (UL, also called fibroids). recruited 81 women UL, 105 ovarian endometrioma (OE), 116 28 both adenomyosis 100 control subjects other acquired gynecological conditions but not endometriosis, or polycystic syndrome. Measurements from the anterior clitoral surface to center of anus (AGDAC), tip clitoris (AGDACt), posterior fourchette (AGDAF) were made in all subjects. Multiple regression was performed estimate association between AGDs presence OE, UL while controlling for possible confounding factors. found that, compared controls, OE had significantly shorter AGDAF, AGDAC. However, amount variance that could be explained by disease status rather moderate, suggesting factors than status, bodyweight height responsible AGD. Thus, prenatal exposure reduced levels androgen may increase risk developing adenomyosis. contribute pathogenesis